Peer-reviewed Literature References (CYP2C8)
2C8 SUBSTRATES:AMODIAQUINEFluvoxamine-tricyclic antidepressant interaction. An accidental finding. [ PMID 11805197 ] Li XQ, Bjorkman A, Andersson TB, Ridderstrom M, Masimirembwa CM. J Pharmacol Exp Ther. 2002 Feb;300(2):399-407. CERIVASTATIN Clinical pharmacokinetics of cerivastatin. [ PMID 10976657 ] Mück W. Clin Pharmacokinet. 2000 Aug;39(2):99-116. Gemfibrozil inhibits CYP2C8-mediated cerivastatin metabolism in human liver microsomes. [ PMID 12433802 ] Wang JS, Neuvonen M, Wen X, Backman JT, Neuvonen PJ. Drug Metab Dispos. 2002 Dec;30(12):1352-6. PACLITAXEL Paclitaxel metabolism in rat and human liver microsomes is inhibited by phenolic antioxidants. [ PMID 12920504 ] Vaclavikova R, Horsky S, Simek P, Gut I. Naunyn Schmiedebergs Arch Pharmacol. 2003 Sep;368(3):200-9. REPAGLINIDE CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide. [ PMID 12919179 ] Bidstrup TB, Bjornsdottir I, Sidelmann UG, Thomsen MS, Hansen KT. Br J Clin Pharmacol. 2003 Sep;56(3):305-14. Polymorphism in CYP2C8 is associated with reduced plasma concentrations of repaglinide. [ PMID 14534525 ] Niemi M, Leathart JB, Neuvonen M, Backman JT, Daly AK, Neuvonen PJ. Clin Pharmacol Ther. 2003 Oct;74(4):380-7. SORAFENIB Prescribing Information TORSEMIDE The xenobiotic inhibitor profile of cytochrome P4502C8. [ PMID 11136296 ] Ong CE, Coulter S, Birkett DJ, Bhasker CR, Miners JO. Br J Clin Pharmacol. 2000 Dec;50(6):573-80. 2C8 INHIBITORS:GEMFIBROZILGemfibrozil inhibits CYP2C8-mediated cerivastatin metabolism in human liver microsomes. [ PMID 12433802 ] Wang JS, Neuvonen M, Wen X, Backman JT, Neuvonen PJ. Drug Metab Dispos. 2002 Dec;30(12):1352-6. Gemfibrozil greatly increases plasma concentrations of cerivastatin. [ PMID 12496749 ] Backman JT, Kyrklund C, Neuvonen M, Neuvonen PJ. Clin Pharmacol Ther. 2002 Dec;72(6):685-91. Gemfibrozil considerably increases the plasma concentrations of rosiglitazone. [ PMID 12898007 ] Niemi M, Backman JT, Granfors M, Laitila J, Neuvonen M, Neuvonen PJ. Diabetologia. 2003 Oct;46(10):1319-23. GLITAZONES (thiazolidinediones) Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition. [ PMID 12642470 ] Sahi J, Black CB, Hamilton GA, Zheng X, Jolley S, Rose KA, Gilbert D, LeCluyse EL, Sinz MW. Drug Metab Dispos. 2003 Apr;31(4):439-46. MONTELUKAST Selective inhibition of human cytochrome P4502C8 by montelukast. [ PMID 15608135 ] Walsky RL, Obach RS, Gaman EA, Gleeson JP, Proctor WR. Drug Metab Dispos. 2005 Mar;33(3):413-8. QUERCETIN Human cytochrome P450s involved in the metabolism of 9-cis- and 13-cis-retinoic acids. [ PMID 11911845 ] Marill J, Capron CC, Idres N, Chabot GG. Biochem Pharmacol. 2002 Mar 1;63(5):933-43. TRIMETHOPRIM Trimethoprim and sulfamethoxazole are selective inhibitors of CYP2C8 and CYP2C9, respectively. [ PMID 12019187 ] Wen X, Wang JS, Backman JT, Laitila J, Neuvonen PJ. Drug Metab Dispos. 2002 Jun;30(6):631-5. Effects of trimethoprim and rifampin on the pharmacokinetics of the cytochrome P450 2C8 substrate rosiglitazone. [ PMID 15371985 ] Niemi M, Backman JT, Neuvonen PJ.. Clin Pharmacol Ther. 2004 Sep;76(3):239-49. The effect of trimethoprim on CYP2C8 mediated rosiglitazone metabolism in human liver microsomes and healthy subjects. [ PMID 15606443 ] Hruska MW, Amico JA, Langaee TY, Ferrell RE, Fitzgerald SM, Frye RF. Br J Clin Pharmacol. 2005 Jan;59(1):70-9. The CYP2C8 inhibitor trimethoprim increases the plasma concentrations of repaglinide in healthy subjects. [ PMID 15025742 ] Niemi M, Kajosaari LI, Neuvonen M, Backman JT, Neuvonen PJ. Br J Clin Pharmacol. 2004 Apr;57(4):441-7. 2C8 INDUCERS:RIFAMPICINExpression and Induction of CYP2C P450 Enzymes in Primary Cultures of Human Hepatocytes. [ PMID 12130704 ] J Pharmacol Exp Ther. 2002 Aug;302(2):475-82. |