(Feb. 8, 2010) — Consuming two or more soft drinks per week increased the risk of developing pancreatic cancer by nearly two-fold compared with individuals who did not consume soft drinks, according to a report in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.
Although relatively rare, pancreatic cancer remains one of the most deadly; only 5 percent of people who are diagnosed survive five years later.
Mark Pereira, PhD, senior author on the study and associate professor in the School of Public Health at the University of Minnesota, and first author Noel Mueller, MPH, said people who consume soft drinks on a regular basis, defined as primarily carbonated sugar-sweetened beverages, tend to have a poor behavioral profile overall.
However, the effect of these drinks on pancreatic cancer may be unique.
"The high levels of sugar in soft drinks may be increasing the level of insulin in the body, which we think contributes to pancreatic cancer cell growth," said Pereira.
More than 60,000 people in study
For the current study, Pereira and colleagues observed 60,524 men and women in the Singapore Chinese Health Study for 14 years. During that time, there were 140 pancreatic cancer cases. Those who consumed two or more soft drinks per week (averaging 5 per week) had an 87 percent increased risk compared with individuals who did not.
No association was seen between fruit juice consumption and pancreatic cancer.
Pereira said that these results from Singapore are likely applicable to the United States.
"Singapore is a wealthy country with excellent health care. Favorite pastimes are eating and shopping, so the findings should apply to other western countries," said Pereira.
Study has key limitations
Susan Mayne, Ph.D., associate director of the Yale Cancer Center and professor of epidemiology at the Yale School of Public Health, said the study had some key limitations that should be considered in any interpretation.
"Although this study found a risk, it remains unclear whether it is a causal association or not. Soft drink consumption in Singapore was associated with several other adverse health behaviors such as smoking and red meat intake, which we can't accurately control for," said Mayne, an editorial board member of Cancer Epidemiology, Biomarkers and Prevention.
Yet Pereira points out that the findings are biologically plausible, held up in non-smokers, remained similar after taking other dietary habits into account, and are consistent with findings in Caucasian populations.
Alicia Wills | June 24, 2010 3:59 PM | Reply
WOW... my father just showed me a shorter version of this article in The American Legion Magazine. This was life changing. No more soft drinks for me. Whatever you have to say about red wine might fall on deaf ears. LoL
colin bannon | September 17, 2010 6:26 AM | Reply
The high intake of added sugar in the american diet seems to be not given enough emphasis by your department. Although the american diet is world famous for all the wrong reasons, the average intake of refined sugar is phenomenal and seem to me to be the elephant in the room. A big, obese elephant! Why not more research in theis area which is so easy to quantify??