It was only a matter of time: Two of Hollywood's most politically active stars are teaming for a political thriller.

George Clooney and Leonardo DiCaprio are in discussions to partner for "Farragut North," based on the upcoming Broadway play by Beau Willimon. Clooney would direct and produce the adaptation, which is set up at Warner Bros., while DiCaprio would star and produce as well.

Titled after the Washington Metro station that is located near many lobbyists' offices, the play is loosely based on Howard Dean's 2004 presidential election campaign, during which Willimon worked for the Democrat.

The story follows a young, idealistic communications director who works for an inspiring, though unorthodox, presidential candidate. During the campaign, his career is done in by more seasoned politicos who thrive on poisonous partisan politics, dirty tricks and back-stabbing.

Willimon, who is adapting his own work, held readings of the play during the summer in which Jake Gyllenhaal participated. The play, which Mike Nichols is slated to direct, is set to open in fall 2008, just before the presidential election.

Clooney would produce with his Smoke House shingle partner, Grant Heslov, while DiCaprio would produce via his Appian Way. Both are based at Warners.

Clooney is onscreen in the corporate thriller "Michael Clayton" and is in postproduction on latest directorial effort, "Leatherheads." He is repped by CAA and Lichter, Grossman, Nichols & Adler.

DiCaprio is filming Ridley Scott's Iraq War thriller "Body of Lies." He is repped by the Firm and Hansen, Jacobson, Teller.